JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL)

JAK3 Is Expressed in the Nucleus of Malignant T Cells in Cutaneous T Cell Lymphoma (CTCL)

Perturbation in JAK-STAT signaling has been reported in the pathogenesis of cutaneous T cell lymphoma (CTCL). JAK3 is predominantly associated with the intra-cytoplasmic part of IL-2Rγc located in the plasma membrane of hematopoietic cells. Here we demonstrate that JAK3 is also ectopically expressed...

Full description

Bibliographic Details
Main Authors: Chella Krishna Vadivel, Maria Gluud, Sara Torres-Rusillo, Lasse Boding, Andreas Willerslev-Olsen, Terkild B. Buus, Tea Kirkegaard Nielsen, Jenny L. Persson, Charlotte M. Bonefeld, Carsten Geisler, Thorbjorn Krejsgaard, Anja T. Fuglsang, Niels Odum, Anders Woetmann
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cancers
Subjects:
JAK3
cutaneous T cell lymphoma
Mycosis fungoides
Sézary syndrome
tyrosine kinases
Online Access:https://www.mdpi.com/2072-6694/13/2/280

Internet

https://www.mdpi.com/2072-6694/13/2/280

Similar Items