Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells

Modulating the unfolded protein response with ONC201 to impact on radiation response in prostate cancer cells

Abstract Prostate cancer (PCa) is the most common non-cutaneous cancer in men and a notable cause of cancer mortality when it metastasises. The unfolded protein response (UPR) can be cytoprotective but when acutely activated can lead to cell death. In this study, we sought to enhance the acute activ...

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Bibliographic Details
Main Authors: Francesca Amoroso, Kimberley Glass, Reema Singh, Francisco Liberal, Rebecca E. Steele, Sarah Maguire, Rohinton Tarapore, Joshua E. Allen, Sandra Van Schaeybroeck, Karl T. Butterworth, Kevin Prise, Joe M. O’Sullivan, Suneil Jain, David J. Waugh, Ian G. Mills
Format: Article
Language:English
Published: Nature Publishing Group 2021-02-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-83215-y

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https://doi.org/10.1038/s41598-021-83215-y

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