Structural Elucidation of Antibiotic TKR2999, an Antifungal Lipodepsipeptide Isolated from the Fungus <i>Foliophoma fallens</i>

Structural Elucidation of Antibiotic TKR2999, an Antifungal Lipodepsipeptide Isolated from the Fungus <i>Foliophoma fallens</i>

An antifungal lipodepsipeptide was obtained from cultures of the fungus <i>Foliophoma fallens</i> CF-236885. Its structure, elucidated by HRMS and NMR spectroscopy, contained Gly, Thr, Asn, β-Ala, Orn, Ala, two Ser residues, and 3-hydroxy-4-methylhexadecanoic acid. The absolute configura...

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Bibliographic Details
Main Authors: Gloria Crespo, Ignacio Pérez-Victoria, Francisco Javier Ortiz-López, Víctor González-Menéndez, Mercedes de la Cruz, Bastien Cautain, Pilar Sánchez, Francisca Vicente, Olga Genilloud, Fernando Reyes
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:Antibiotics
Subjects:
<i>Foliophoma fallens</i>
antibiotic TKR2999
lipodepsipeptide
structural elucidation
Marfey’s analysis
antifungal activity
Online Access:https://www.mdpi.com/2079-6382/9/6/278

Internet

https://www.mdpi.com/2079-6382/9/6/278

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