NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy

NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy

Background NKTR-255 is a novel polyethylene glycol-conjugate of recombinant human interleukin-15 (rhIL-15), which was designed to retain all known receptor binding interactions of the IL-15 molecule. We explored the biologic and pharmacologic differences between endogenous IL-15 receptor α (IL-15Rα)...

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Bibliographic Details
Main Authors: Peter Kirk, Murali Addepalli, Thomas Chang, Palakshi Obalapur, Peiwen Kuo, Phi Quach, Jonathan Zalevsky, Rhoneil Pena, Saul Kivimae, Werner Rubas, Takahiro Miyazaki, Loui Madakamutil, Mekhala Maiti, Marlene Hennessy, Sara Sheibani, Joanna Wilczek, Janet Cetz, Andrew Moffett, Yinyan Tang, Jicai Huang, Dawei Sheng
Format: Article
Language:English
Published: BMJ Publishing Group 2021-05-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/9/5/e002024.full

Internet

https://jitc.bmj.com/content/9/5/e002024.full

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