Novel Survivin Inhibitor YM155 elicits Cytotoxicity in Glioblastoma Cell Lines with Normal or Deficiency DNA-Dependent Protein Kinase Activity

Novel Survivin Inhibitor YM155 elicits Cytotoxicity in Glioblastoma Cell Lines with Normal or Deficiency DNA-Dependent Protein Kinase Activity

Pediatric glioblastoma is a malignant disease with an extremely poor clinical outcome. Patients usually suffer from resistance to radiation therapy, so targeted drug treatment may be a new possibility for glioblastoma therapy. Survivin is also overexpressed in glioblastoma. YM155, a novel small-mole...

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Bibliographic Details
Main Authors: Pei Chun Lai, Shu Huey Chen, Shang Hsien Yang, Chuan Chu Cheng, Ted H. Chiu, Yen Ta Huang
Format: Article
Language:English
Published: Elsevier 2012-06-01
Series:Pediatrics and Neonatology
Subjects:
glioblastoma
DNA-dependent protein kinase
securin
surviving
YM155
Online Access:http://www.sciencedirect.com/science/article/pii/S1875957212000587

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http://www.sciencedirect.com/science/article/pii/S1875957212000587

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