The emperor's new clothes: PDE5 and the heart.

Phosphodiesterase-5 (PDE5) is highly expressed in the pulmonary vasculature, but its expression in the myocardium is controversial. Cyclic guanosine monophosphate (cGMP) activates protein kinase G (PKG), which has been hypothesized to blunt cardiac hypertrophy and negative remodeling in heart failur...

Full description

Bibliographic Details
Main Authors: Chantal V Degen, Kalkidan Bishu, Rosita Zakeri, Ozgur Ogut, Margaret M Redfield, Frank V Brozovich
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4351884?pdf=render