Time-Dependent Distribution of Hydroxychloroquine in Cynomolgus Macaques Using Population Pharmacokinetic Modeling Method

Time-Dependent Distribution of Hydroxychloroquine in Cynomolgus Macaques Using Population Pharmacokinetic Modeling Method

To evaluate the biodistribution of hydroxychloroquine (HCQ) in cynomolgus macaques and receive dynamic quantitative relationship between plasma, blood, and lung tissue concentration using the population pharmacokinetic modeling method, seventeen cynomolgus macaques were divided into six groups accor...

Full description

Bibliographic Details
Main Authors: Qi Liu, Guofang Bi, Guiying Chen, Xuan Guo, Siqi Tu, Xiaolin Tong, Man Xu, Mengjie Liu, Bei Wang, Hongliang Jiang, Jufeng Wang, Haiyan Li, Kun Wang, Dongyang Liu, Chunli Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-01-01
Series:Frontiers in Pharmacology
Subjects:
hydroxychloroquine
biodistribution
population pharmacokinetics
cynomolgus macaques
time-dependent
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2020.602880/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2020.602880/full

Similar Items