Bcl-2 upregulation and neuroprotection in guinea pig brain following chronic simvastatin treatment

The present study determined if chronic simvastatin administration in vivo would provide neuroprotection in brain cells isolated from guinea pigs after challenge with the Bcl-2 inhibitor HA 14-1 or the NO donor sodium nitroprusside (SNP). Bcl-2 levels were significantly increased in brains of simvas...

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Bibliographic Details
Main Authors: Cornelia Franke, Michael Nöldner, Reham Abdel-Kader, Leslie N. Johnson-Anuna, W. Gibson Wood, Walter E. Müller, Gunter P. Eckert
Format: Article
Language:English
Published: Elsevier 2007-02-01
Series:Neurobiology of Disease
Subjects:
Bax
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106002725