TNFα-mediated liver destruction by Kupffer cells and Ly6Chi monocytes during Entamoeba histolytica infection.

Amebic liver abscess (ALA) is a focal destruction of liver tissue due to infection by the protozoan parasite Entamoeba histolytica (E. histolytica). Host tissue damage is attributed mainly to parasite pathogenicity factors, but massive early accumulation of mononuclear cells, including neutrophils,...

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Bibliographic Details
Main Authors: Elena Helk, Hannah Bernin, Thomas Ernst, Harald Ittrich, Thomas Jacobs, Joerg Heeren, Frank Tacke, Egbert Tannich, Hannelore Lotter
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC3536671?pdf=render