Gangliosides do not affect ABC transporter function in human neuroblastoma cells

Gangliosides do not affect ABC transporter function in human neuroblastoma cells

Previous studies have indicated a role for glucosylceramide synthase (GCS) in multidrug resistance (MDR), either related to turnover of ceramide (Cer) or generation of gangliosides, which modulate apoptosis and/or the activity of ABC transporters. This study challenges the hypothesis that gangliosid...

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Bibliographic Details
Main Authors: Anne-Jan Dijkhuis, Karin Klappe, Willem Kamps, Hannie Sietsma, Jan Willem Kok
Format: Article
Language:English
Published: Elsevier 2006-06-01
Series:Journal of Lipid Research
Subjects:
glucosylceramide synthase
d,l-threo-1-phenyl-2-hexadecanoylamino-3-pyrrolidino-1-propanol
N-butyldeoxynojirimycin
P-glycoprotein
multidrug resistance-related protein 1
detergent-resistant membrane
Online Access:http://www.sciencedirect.com/science/article/pii/S002222752033217X

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http://www.sciencedirect.com/science/article/pii/S002222752033217X

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