Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation

Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation

The incidence of cardiovascular disease (CVD) is higher in cancer survivors than in the general population. Several cancer treatments are recognized as risk factors for CVD, but specific therapies are unavailable. Many cancer treatments activate shared signaling events, which reprogram myeloid cells...

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Main Authors: Sivareddy Kotla, Aijun Zhang, Masaki Imanishi, Kyung Ae Ko, Steven H. Lin, Young Jin Gi, Margie Moczygemba, Sevinj Isgandarova, Keri L. Schadler, Caroline Chung, Sarah A. Milgrom, Jose Banchs, Syed Wamique Yusuf, Diana N. Amaya, Huifang Guo, Tamlyn N. Thomas, Ying H. Shen, Anita Deswal, Joerg Herrmann, Eugenie S. Kleinerman, Mark L. Entman, John P. Cooke, Giovanni Schifitto, Sanjay B. Maggirwar, Elena McBeath, Anisha A. Gupte, Sunil Krishnan, Zarana S. Patel, Yisang Yoon, Jared K. Burks, Keigi Fujiwara, Paul S. Brookes, Nhat-Tu Le, Dale J. Hamilton, Jun-ichi Abe
Format: Article
Language:English
Published: Elsevier 2021-11-01
Series:Redox Biology
Subjects:
Mitochondrial stunning
Atherosclerosis
Senescence-associated secretory phenotype (SASP)
Efferocytosis
Antioxidants
Telomere length
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231721002913

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http://www.sciencedirect.com/science/article/pii/S2213231721002913

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