Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint

Augmented antitumor activity by olaparib plus AZD1775 in gastric cancer through disrupting DNA damage repair pathways and DNA damage checkpoint

Abstract Background Targeting poly ADP-ribose polymerase (PARP) has been recently identified as a promising option against gastric cancer (GC). However, PARP inhibitors alone achieve limited efficacy. Combination strategies, especially with homologous recombination (HR) impairment, are of great hope...

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Bibliographic Details
Main Authors: Xiaoting Lin, Dongshao Chen, Cheng Zhang, Xiaotian Zhang, Zhongwu Li, Bin Dong, Jing Gao, Lin Shen
Format: Article
Language:English
Published: BMC 2018-06-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
PARP inhibitor
WEE1/PLK1 dual inhibitor
Combination
Gastric cancer
HR deficiency
DNA damage checkpoint
Online Access:http://link.springer.com/article/10.1186/s13046-018-0790-7

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http://link.springer.com/article/10.1186/s13046-018-0790-7

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