Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice

Retinitis pigmentosa is mainly caused by mutations that initially affect survival of rod photoreceptors, leading to secondary loss of cones. Here the authors use gene editing to prevent rod degeneration, leading to survival of cones and improved vision in mice.

Bibliographic Details
Main Authors: Wenhan Yu, Suddhasil Mookherjee, Vijender Chaitankar, Suja Hiriyanna, Jung-Woong Kim, Matthew Brooks, Yasaman Ataeijannati, Xun Sun, Lijin Dong, Tiansen Li, Anand Swaroop, Zhijian Wu
Format: Article
Language:English
Published: Nature Publishing Group 2017-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms14716

Internet

https://doi.org/10.1038/ncomms14716

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