Extracellular Alpha-Synuclein Promotes a Neuroinhibitory Secretory Phenotype in Astrocytes

Extracellular Alpha-Synuclein Promotes a Neuroinhibitory Secretory Phenotype in Astrocytes

Multiple system atrophy (MSA) and dementia with Lewy bodies (DLB) are α-synucleinopathies that exhibit widespread astrogliosis as a component of the neuroinflammatory response. Munc18, a protein critical to vesicle exocytosis, was previously found to strongly mark morphologically activated astrocyte...

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Bibliographic Details
Main Authors: Bruno Di Marco Vieira, Rowan A. W. Radford, Junna Hayashi, Emma D. Eaton, Ben Greenaway, Mark Jambas, Eugen B. Petcu, Roger S. Chung, Dean L. Pountney
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Life
Subjects:
astrocytes
astrogliosis
MSA
DLB
Munc18
Online Access:https://www.mdpi.com/2075-1729/10/9/183

Internet

https://www.mdpi.com/2075-1729/10/9/183

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