Late-Onset Antibody Deficiency Due to Monoallelic Alterations in NFKB1

Late-Onset Antibody Deficiency Due to Monoallelic Alterations in NFKB1

Adult-onset primary immunodeficiency is characterized by recurrent infections, hypogammaglobulinemia, and poor antibody response to vaccines. In this study, we have analyzed targeted gene panel sequencing results of 270 patients diagnosed with antibody deficiency and identified five disease-associat...

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Bibliographic Details
Main Authors: Claudia Schröder, Georgios Sogkas, Manfred Fliegauf, Thilo Dörk, Di Liu, Leif G. Hanitsch, Sophie Steiner, Carmen Scheibenbogen, Roland Jacobs, Bodo Grimbacher, Reinhold E. Schmidt, Faranaz Atschekzei
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Immunology
Subjects:
nuclear factor kappa B subunit 1
combined immunodeficiency
common variable immunodeficiency
NFKB1 haploinsufficiency
hypogammaglobulinemia
late-onset antibody deficiency
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.02618/full

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https://www.frontiersin.org/article/10.3389/fimmu.2019.02618/full

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