Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy

Tolerability and efficacy study of P2X7 inhibition in experimental Charcot-Marie-Tooth type 1A (CMT1A) neuropathy

Charcot-Marie-Tooth 1A (CMT1A) is a demyelinating hereditary neuropathy for which pharmacological treatments are not yet available. An abnormally high intracellular Ca2+ concentration was observed in Schwann cells (SC) from CMT1A rats, caused by the PMP22-mediated overexpression of the P2X7 purinoce...

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Bibliographic Details
Main Authors: Giovanna Sociali, Davide Visigalli, Thomas Prukop, Ilaria Cervellini, Elena Mannino, Consuelo Venturi, Santina Bruzzone, Michael W. Sereda, Angelo Schenone
Format: Article
Language:English
Published: Elsevier 2016-11-01
Series:Neurobiology of Disease
Subjects:
CMT1A
PMP22
P2X7
Myelination
SC differentiation markers
Grip strength test
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996116301735

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http://www.sciencedirect.com/science/article/pii/S0969996116301735

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