In vivo Dominant-Negative Effect of an SCN5A Brugada Syndrome Variant

In vivo Dominant-Negative Effect of an SCN5A Brugada Syndrome Variant

Loss-of-function mutations in the cardiac Na+ channel α-subunit Nav1.5, encoded by SCN5A, cause Brugada syndrome (BrS), a hereditary disease characterized by sudden cardiac death due to ventricular fibrillation. We previously evidenced in vitro the dominant-negative effect of the BrS Nav1.5-R104W va...

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Bibliographic Details
Main Authors: Nicolas Doisne, Marta Grauso, Nathalie Mougenot, Michel Clergue, Charlotte Souil, Alain Coulombe, Pascale Guicheney, Nathalie Neyroud
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Physiology
Subjects:
Brugada syndrome
Nav1.5
SCN5A
animal model
electrophysiology
AAV
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.661413/full

Internet

https://www.frontiersin.org/articles/10.3389/fphys.2021.661413/full

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