Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression

Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression

Abstract Background The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role during early mammalian development and pluripotency. While multiple g...

Full description

Bibliographic Details
Main Authors: Michael Reimer, Kirthi Pulakanti, Linzheng Shi, Alex Abel, Mingyu Liang, Subramaniam Malarkannan, Sridhar Rao
Format: Article
Language:English
Published: BMC 2019-07-01
Series:BMC Developmental Biology
Subjects:
Embryonic stem cells
DNA methylation
Ten eleven translocation (TET proteins)
Differentiation
Online Access:http://link.springer.com/article/10.1186/s12861-019-0196-6

Internet

http://link.springer.com/article/10.1186/s12861-019-0196-6

Similar Items