Deletion of Tet proteins results in quantitative disparities during ESC differentiation partially attributable to alterations in gene expression
Abstract Background The Tet protein family (Tet1, Tet2, and Tet3) regulate DNA methylation through conversion of 5-methylcytosine to 5-hydroxymethylcytosine which can ultimately result in DNA demethylation and play a critical role during early mammalian development and pluripotency. While multiple g...
Main Authors: | Michael Reimer, Kirthi Pulakanti, Linzheng Shi, Alex Abel, Mingyu Liang, Subramaniam Malarkannan, Sridhar Rao |
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Format: | Article |
Language: | English |
Published: |
BMC
2019-07-01
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Series: | BMC Developmental Biology |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12861-019-0196-6 |
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