A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic Morphology

A Caenorhabditis elegans Model for Integrating the Functions of Neuropsychiatric Risk Genes Identifies Components Required for Normal Dendritic Morphology

Analysis of patient-derived DNA samples has identified hundreds of variants that are likely involved in neuropsychiatric diseases such as autism spectrum disorder (ASD) and schizophrenia (SCZ). While these studies couple behavioral phenotypes to individual genotypes, the number and diversity of cand...

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Bibliographic Details
Main Authors: Cristina Aguirre-Chen, Natalia Stec, Olivia Mendivil Ramos, Nuri Kim, Melissa Kramer, Shane McCarthy, Jesse Gillis, W. Richard McCombie, Christopher M. Hammell
Format: Article
Language:English
Published: Oxford University Press 2020-05-01
Series:G3: Genes, Genomes, Genetics
Subjects:
caenorhabditis elegans
autism spectrum disorder
schizophrenia
neuropsychiatric risk genes
rna interference
dendritic arborization
model organism
neuronal development
Online Access:http://g3journal.org/lookup/doi/10.1534/g3.119.400925

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http://g3journal.org/lookup/doi/10.1534/g3.119.400925

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