Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

Pulmonary inflammation-induced loss and subsequent recovery of skeletal muscle mass require functional poly-ubiquitin conjugation

Abstract Background Pulmonary inflammation in response to respiratory infections can evoke muscle wasting. Increased activity of the ubiquitin (Ub)-proteasome system (UPS) and the autophagy lysosome pathway (ALP) have been implicated in inflammation-induced muscle atrophy. Since poly-Ub conjugation...

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Bibliographic Details
Main Authors: Judith J. M. Ceelen, Annemie M. W. J. Schols, Nathalie G. M. Thielen, Astrid Haegens, Douglas A. Gray, Marco C. J. M. Kelders, Chiel C. de Theije, Ramon C. J. Langen
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Respiratory Research
Subjects:
Inflammation
Skeletal muscle atrophy
Autophagy
Poly-ubiquitin
Proteolysis
Protein synthesis
Online Access:http://link.springer.com/article/10.1186/s12931-018-0753-8

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http://link.springer.com/article/10.1186/s12931-018-0753-8

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