TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion

TLR7 Controls VSV Replication in CD169+ SCS Macrophages and Associated Viral Neuroinvasion

Vesicular stomatitis virus (VSV) is an insect-transmitted rhabdovirus that is neurovirulent in mice. Upon peripheral VSV infection, CD169+ subcapsular sinus (SCS) macrophages capture VSV in the lymph, support viral replication, and prevent CNS neuroinvasion. To date, the precise mechanisms controlli...

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Bibliographic Details
Main Authors: Gülhas Solmaz, Franz Puttur, Marcela Francozo, Marc Lindenberg, Melanie Guderian, Maxine Swallow, Vikas Duhan, Vishal Khairnar, Ulrich Kalinke, Burkhard Ludewig, Björn E. Clausen, Hermann Wagner, Karl S. Lang, Tim D. Sparwasser
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-03-01
Series:Frontiers in Immunology
Subjects:
pattern recognition receptors
Toll-like receptor 7
vesicular stomatitis virus
virus replication
innate immunity
subcapsular sinus macrophages
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.00466/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.00466/full

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