Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress

Gut Metabolite TMAO Induces Synaptic Plasticity Deficits by Promoting Endoplasmic Reticulum Stress

Dysbiosis of gut microbiota is strongly associated with metabolic diseases including diabetes mellitus, obesity, and cardiovascular disease. Recent studies indicate that Trimethylamine N-oxide (TMAO), a gut microbe-dependent metabolite is implicated in the development of age-related cognitive declin...

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Bibliographic Details
Main Authors: Manoj Govindarajulu, Priyanka D. Pinky, Ian Steinke, Jenna Bloemer, Sindhu Ramesh, Thiruchelvan Kariharan, Robert T. Rella, Subhrajit Bhattacharya, Muralikrishnan Dhanasekaran, Vishnu Suppiramaniam, Rajesh H. Amin
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Molecular Neuroscience
Subjects:
trimethylamine N-oxide (TMAO)
synaptic plasticity
long-term potentiation (LTP)
endoplasmic reticulum stress (ER stress)
insulin resistance
Alzheimer’s disease
Online Access:https://www.frontiersin.org/article/10.3389/fnmol.2020.00138/full

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https://www.frontiersin.org/article/10.3389/fnmol.2020.00138/full

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