Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes crucial for maturation.

Transcriptome-guided functional analyses reveal novel biological properties and regulatory hierarchy of human embryonic stem cell-derived ventricular cardiomyocytes crucial for maturation.

Human (h) embryonic stem cells (ESC) represent an unlimited source of cardiomyocytes (CMs); however, these differentiated cells are immature. Thus far, gene profiling studies have been performed with non-purified or non-chamber specific CMs. Here we took a combinatorial approach of using systems bio...

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Bibliographic Details
Main Authors: Ellen Poon, Bin Yan, Shaohong Zhang, Stephanie Rushing, Wendy Keung, Lihuan Ren, Deborah K Lieu, Lin Geng, Chi-Wing Kong, Jiaxian Wang, Hau San Wong, Kenneth R Boheler, Ronald A Li
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3804624?pdf=render

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http://europepmc.org/articles/PMC3804624?pdf=render

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