Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors

Computer-Driven Development of an in Silico Tool for Finding Selective Histone Deacetylase 1 Inhibitors

Histone deacetylases (HDACs) are a class of epigenetic modulators overexpressed in numerous types of cancers. Consequently, HDAC inhibitors (HDACIs) have emerged as promising antineoplastic agents. Unfortunately, the most developed HDACIs suffer from poor selectivity towards a specific isoform, limi...

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Bibliographic Details
Main Authors: Hajar Sirous, Giuseppe Campiani, Simone Brogi, Vincenzo Calderone, Giulia Chemi
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:Molecules
Subjects:
3D-QSAR
pharmacophore modeling
ligand-based model
HDACs
isoform-selective histone deacetylase inhibitors
aminophenylbenzamide
Online Access:https://www.mdpi.com/1420-3049/25/8/1952

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https://www.mdpi.com/1420-3049/25/8/1952

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