Chitosan-Based Polyelectrolyte Complexes for Doxorubicin and Zoledronic Acid Combined Therapy to Overcome Multidrug Resistance

Chitosan-Based Polyelectrolyte Complexes for Doxorubicin and Zoledronic Acid Combined Therapy to Overcome Multidrug Resistance

This study aimed to develop nanovectors co-encapsulating doxorubicin (Doxo) and zoledronic acid (Zol) for a combined therapy against Doxo-resistant tumors. Chitosan (CHI)-based polyelectrolyte complexes (PECs) prepared by ionotropic gelation technique were proposed. The influence of some experimenta...

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Bibliographic Details
Main Authors: Simona Giarra, Silvia Zappavigna, Virginia Campani, Marianna Abate, Alessia Maria Cossu, Carlo Leonetti, Manuela Porru, Laura Mayol, Michele Caraglia, Giuseppe De Rosa
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:Pharmaceutics
Subjects:
chitosan
polyelectrolyte complexes
doxorubicin
zoledronic acid
multidrug resistance
Online Access:http://www.mdpi.com/1999-4923/10/4/180

Internet

http://www.mdpi.com/1999-4923/10/4/180

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