Tongxinluo Inhibits Cyclooxygenase-2, Inducible Nitric Oxide Synthase, Hypoxia-inducible Factor-2α/Vascular Endothelial Growth Factor to Antagonize Injury in Hypoxia-stimulated Cardiac Microvascular Endothelial Cells

Tongxinluo Inhibits Cyclooxygenase-2, Inducible Nitric Oxide Synthase, Hypoxia-inducible Factor-2α/Vascular Endothelial Growth Factor to Antagonize Injury in Hypoxia-stimulated Cardiac Microvascular Endothelial Cells

Background: Endothelial dysfunction is considered as the initiating process and pathological basis of cardiovascular disease. Cyclooxygenase-2 (COX-2) and prostacyclin synthase (PGIS), inducible nitric oxide synthase (iNOS) and endothelial NOS (eNOS) are key enzymes with opposing actions in inflamma...

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Bibliographic Details
Main Authors: Yan-Ning Li, Xiu-Juan Wang, Bin Li, Kun Liu, Jin-Sheng Qi, Bing-Hui Liu, Ye Tian
Format: Article
Language:English
Published: Wolters Kluwer 2015-01-01
Series:Chinese Medical Journal
Subjects:
Cyclooxygenase-2; Hypoxia-inducible Factor-2α; Hypoxia; Inducible Nitric Oxide Synthase; Tongxinluo; Vascular Endothelial Growth Factor
Online Access:http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=8;spage=1114;epage=1120;aulast=Li

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http://www.cmj.org/article.asp?issn=0366-6999;year=2015;volume=128;issue=8;spage=1114;epage=1120;aulast=Li

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