CD4+ T Helper Cells Play a Key Role in Maintaining Diabetogenic CD8+ T Cell Function in the Pancreas

CD4+ T Helper Cells Play a Key Role in Maintaining Diabetogenic CD8+ T Cell Function in the Pancreas

Autoreactive CD8+ and CD4+ T cells have been assigned independent key roles in the destruction of insulin-producing beta cells resulting in type 1 diabetes. Although CD4 help for the generation of efficient CD8+ T cell responses in lymphoid tissue has been extensively described, whether these two ce...

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Bibliographic Details
Main Authors: Gabriel Espinosa-Carrasco, Cécile Le Saout, Pierre Fontanaud, Thomas Stratmann, Patrice Mollard, Marie Schaeffer, Javier Hernandez
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-01-01
Series:Frontiers in Immunology
Subjects:
autoimmunity
CD4 help
effector CD8+ T cells
type 1 diabetes
imaging
in vivo
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.02001/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.02001/full

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