Eliminating acetate formation improves citramalate production by metabolically engineered Escherichia coli
Abstract Background Citramalate, a chemical precursor to the industrially important methacrylic acid (MAA), can be synthesized using Escherichia coli overexpressing citramalate synthase (cimA gene). Deletion of gltA encoding citrate synthase and leuC encoding 3-isopropylmalate dehydratase were criti...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2017-06-01
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Series: | Microbial Cell Factories |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s12934-017-0729-2 |