Eliminating acetate formation improves citramalate production by metabolically engineered Escherichia coli

Eliminating acetate formation improves citramalate production by metabolically engineered Escherichia coli

Abstract Background Citramalate, a chemical precursor to the industrially important methacrylic acid (MAA), can be synthesized using Escherichia coli overexpressing citramalate synthase (cimA gene). Deletion of gltA encoding citrate synthase and leuC encoding 3-isopropylmalate dehydratase were criti...

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Bibliographic Details
Main Authors: Naga Sirisha Parimi, Ian A. Durie, Xianghao Wu, Afaq M. M. Niyas, Mark A. Eiteman
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Microbial Cell Factories
Subjects:
Acetyl-CoA
Pyruvate
Citramalate
Escherichia coli
Acetate
Glucose
Online Access:http://link.springer.com/article/10.1186/s12934-017-0729-2

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http://link.springer.com/article/10.1186/s12934-017-0729-2

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