FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability

FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability

Fernandes et al. discover a connection between the mitochondrial stress response and genomic stability. They find that transcription of common fragile site (CFS) genes is induced by mitochondrial stress, whereas a regulator of CFS stability, FANCD2, acts to dampen the mitochondrial stress response a...

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Bibliographic Details
Main Authors: Philippe Fernandes, Benoit Miotto, Claude Saint-Ruf, Maha Said, Viviana Barra, Viola Nähse, Silvia Ravera, Enrico Cappelli, Valeria Naim
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01647-8

Internet

https://doi.org/10.1038/s42003-021-01647-8

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