FANCD2 modulates the mitochondrial stress response to prevent common fragile site instability
Fernandes et al. discover a connection between the mitochondrial stress response and genomic stability. They find that transcription of common fragile site (CFS) genes is induced by mitochondrial stress, whereas a regulator of CFS stability, FANCD2, acts to dampen the mitochondrial stress response a...
Main Authors: | Philippe Fernandes, Benoit Miotto, Claude Saint-Ruf, Maha Said, Viviana Barra, Viola Nähse, Silvia Ravera, Enrico Cappelli, Valeria Naim |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2021-01-01
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Series: | Communications Biology |
Online Access: | https://doi.org/10.1038/s42003-021-01647-8 |
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