Translation affects mRNA stability in a codon-dependent manner in human cells

Translation affects mRNA stability in a codon-dependent manner in human cells

mRNA translation decodes nucleotide into amino acid sequences. However, translation has also been shown to affect mRNA stability depending on codon composition in model organisms, although universality of this mechanism remains unclear. Here, using three independent approaches to measure exogenous a...

Full description

Bibliographic Details
Main Authors: Qiushuang Wu, Santiago Gerardo Medina, Gopal Kushawah, Michelle Lynn DeVore, Luciana A Castellano, Jacqelyn M Hand, Matthew Wright, Ariel Alejandro Bazzini
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-04-01
Series:eLife
Subjects:
codon optimality
mRNA stability
translation
tRNA
poly(A)-tail
SLAM-seq
Online Access:https://elifesciences.org/articles/45396

Internet

https://elifesciences.org/articles/45396

Similar Items