Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones

Synthesis and Antitumor Evaluation of 6-Aryl-substituted benzo[j]phenanthridine- and Benzo[g]pyrimido[4,5-c]isoquinolinequinones

A variety of novel 6-arylsubstituted benzo[j]phenanthridine- and benzo[g]-pyrimido[4,5-c]isoquinolinequinones were synthesized from 1,4-naphthoquinone, aryl-aldehydes and enaminones via a two-step synthetic approach. The cytotoxic activity of the aminoquinone derivatives was evaluated in vitro again...

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Bibliographic Details
Main Authors: Jennyfer Iribarra, David Vásquez, Cristina Theoduloz, Julio Benites, David Ríos, Jaime A. Valderrama
Format: Article
Language:English
Published: MDPI AG 2012-09-01
Series:Molecules
Subjects:
N-heterocyclic quinones
enaminones
cytotoxicity
SAR analysis
Online Access:http://www.mdpi.com/1420-3049/17/10/11616

Internet

http://www.mdpi.com/1420-3049/17/10/11616

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