RET Recognition of GDNF-GFRα1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association

RET Recognition of GDNF-GFRα1 Ligand by a Composite Binding Site Promotes Membrane-Proximal Self-Association

The RET receptor tyrosine kinase is essential to vertebrate development and implicated in multiple human diseases. RET binds a cell surface bipartite ligand comprising a GDNF family ligand and a GFRα coreceptor, resulting in RET transmembrane signaling. We present a hybrid structural model, derived...

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Bibliographic Details
Main Authors: Kerry M. Goodman, Svend Kjær, Fabienne Beuron, Phillip P. Knowles, Agata Nawrotek, Emily M. Burns, Andrew G. Purkiss, Roger George, Massimo Santoro, Edward P. Morris, Neil Q. McDonald
Format: Article
Language:English
Published: Elsevier 2014-09-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124714007165

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http://www.sciencedirect.com/science/article/pii/S2211124714007165

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