Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

Kv1.3 Channel Blockade Modulates the Effector Function of B Cells in Granulomatosis with Polyangiitis

B cells are central to the pathogenesis of granulomatosis with polyangiitis (GPA), exhibiting both (auto)antibody-dependent and -independent properties. Class-switched memory B cells in particular are a major source of pathogenic autoantibodies. These cells are characterized by high expression level...

Full description

Bibliographic Details
Main Authors: Judith Land, Lucas L. Lintermans, Coen A. Stegeman, Ernesto J. Muñoz-Elías, Eric J. Tarcha, Shawn P. Iadonato, Peter Heeringa, Abraham Rutgers, Wayel H. Abdulahad
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-09-01
Series:Frontiers in Immunology
Subjects:
granulomatosis and polyangiitis
B cells
Kv1.3 potassium channels
antineutrophil cytoplasmic antibody
cytokines
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.01205/full

Internet

http://journal.frontiersin.org/article/10.3389/fimmu.2017.01205/full

Similar Items