Immunoproteasomes Control the Homeostasis of Medullary Thymic Epithelial Cells by Alleviating Proteotoxic Stress

Immunoproteasomes Control the Homeostasis of Medullary Thymic Epithelial Cells by Alleviating Proteotoxic Stress

The sole nonredundant role of the thymic medulla is to induce central tolerance, a vital process that depends on promiscuous gene expression (pGE), a unique feature of medullary thymic epithelial cells (mTECs). Although pGE enhances transcription of >3,000 genes in mTECs, its impact on the regula...

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Bibliographic Details
Main Authors: Charles St-Pierre, Erwan Morgand, Mohamed Benhammadi, Alexandre Rouette, Marie-Pierre Hardy, Louis Gaboury, Claude Perreault
Format: Article
Language:English
Published: Elsevier 2017-11-01
Series:Cell Reports
Subjects:
thymic epithelial cells
thymic involution
self-tolerance
promiscuous gene expression
immunoproteasomes
proteotoxic stress
autoimmunity
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717316017

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http://www.sciencedirect.com/science/article/pii/S2211124717316017

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