Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment

Efficient Expression of HIV in Immunocompetent Mouse Brain Reveals a Novel Nonneurotoxic Viral Function in Hippocampal Synaptodendritic Injury and Memory Impairment

HIV neuropathogenesis has been attributed in large measure to neurotoxicity of viral proteins and inflammatory factors produced by infected monocytic cells in the brain. We show here that HIV expression in mouse brain causes lasting memory impairment by a mechanism involving injury to hippocampal sy...

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Bibliographic Details
Main Authors: Jennifer Kelschenbach, Hongxia He, Boe-Hyun Kim, Alejandra Borjabad, Chao-Jiang Gu, Wei Chao, Meilan Do, Leroy R. Sharer, Hong Zhang, Ottavio Arancio, Mary Jane Potash, David J. Volsky
Format: Article
Language:English
Published: American Society for Microbiology 2019-07-01
Series:mBio
Subjects:
ecohiv
hand
mouse models
radial arm water maze
synaptodendritic injury
Online Access:https://doi.org/10.1128/mBio.00591-19

Internet

https://doi.org/10.1128/mBio.00591-19

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