An enhanced genetic model of colorectal cancer progression history

An enhanced genetic model of colorectal cancer progression history

Abstract Background The classical genetic model of colorectal cancer presents APC mutations as the earliest genomic alterations, followed by KRAS and TP53 mutations. However, the timing and relative order of clonal expansion and other types of genomic alterations, such as genomic rearrangements, are...

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Bibliographic Details
Main Authors: Lixing Yang, Su Wang, Jake June-Koo Lee, Semin Lee, Eunjung Lee, Eve Shinbrot, David A. Wheeler, Raju Kucherlapati, Peter J. Park
Format: Article
Language:English
Published: BMC 2019-08-01
Series:Genome Biology
Subjects:
Tumor evolution
Tumor heterogeneity
Aneuploidy
Kataegis
Online Access:http://link.springer.com/article/10.1186/s13059-019-1782-4

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http://link.springer.com/article/10.1186/s13059-019-1782-4

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