The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response
Abstract Background Caspase-8 is a well-established initiator of apoptosis and suppressor of necroptosis, but maintains functions beyond cell death that involve suppression of receptor-interacting serine-threonine kinases (RIPKs). A genome-wide association study meta-analysis revealed an SNP associa...
Main Authors: | , , , , |
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Format: | Article |
Language: | English |
Published: |
BMC
2017-10-01
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Series: | Arthritis Research & Therapy |
Subjects: | |
Online Access: | http://link.springer.com/article/10.1186/s13075-017-1436-4 |