The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response

The caspase-8/RIPK3 signaling axis in antigen presenting cells controls the inflammatory arthritic response

Abstract Background Caspase-8 is a well-established initiator of apoptosis and suppressor of necroptosis, but maintains functions beyond cell death that involve suppression of receptor-interacting serine-threonine kinases (RIPKs). A genome-wide association study meta-analysis revealed an SNP associa...

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Bibliographic Details
Main Authors: Salina Dominguez, Anna B. Montgomery, G. Kenneth Haines, Christina L. Bloomfield, Carla M. Cuda
Format: Article
Language:English
Published: BMC 2017-10-01
Series:Arthritis Research & Therapy
Subjects:
Caspase-8
RIPK3
Rheumatoid arthritis
Dendritic cells
Macrophages
Online Access:http://link.springer.com/article/10.1186/s13075-017-1436-4

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http://link.springer.com/article/10.1186/s13075-017-1436-4

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