Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice

Vindoline Inhibits RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss in Mice

Osteolytic bone diseases, for example postmenopausal osteoporosis, arise from the imbalances between osteoclasts and osteoblasts in the bone remodeling process, whereby osteoclastic bone resorption greatly exceeds osteoblastic bone formation resulting in severe bone loss and deterioration in bone st...

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Bibliographic Details
Main Authors: Yunfei Zhan, Jiamin Liang, Kun Tian, Zhigang Che, Ziyi Wang, Xue Yang, Yuangang Su, Xixi Lin, Fangming Song, Jinmin Zhao, Jiake Xu, Qian Liu, Bo Zhou
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Pharmacology
Subjects:
vindoline
MAPK
osteoclast
osteoporosis
NFATc1
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01587/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01587/full

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