Role of stable hydrogen isotope variations in water for drug dissolution managing

Role of stable hydrogen isotope variations in water for drug dissolution managing

In the present work, we provide the results of defining by utilizing Laser diffraction spectroscopy, the kinetic isotopic effect of solvent and constant of dissolution rate κ, s−1 of аn active pharmaceutical ingredient (API) in water with a different content of a stable 21H_2^1{\rm{H}} isotope on th...

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Bibliographic Details
Main Authors: Uspenskaya Elena V., Pleteneva Tatyana V., Syroeshkin Anton V., Kazimova Ilaha V., Elizarova Tatyana E., Odnovorov Artem I.
Format: Article
Language:English
Published: Sciendo 2020-06-01
Series:Current Issues in Pharmacy and Medical Sciences
Subjects:
kinetics dissolving
laser diffraction spectroscopy
deuterium depleted water (ddw)
kinetic isotope effect (kies)
water clusters
antibacterial
neuroprotective drugs
Online Access:http://www.degruyter.com/view/j/cipms.2020.33.issue-2/cipms-2020-0017/cipms-2020-0017.xml?format=INT

Internet

http://www.degruyter.com/view/j/cipms.2020.33.issue-2/cipms-2020-0017/cipms-2020-0017.xml?format=INT

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