LAG-3-Expressing Tumor-Infiltrating T Cells Are Associated with Reduced Disease-Free Survival in Pancreatic Cancer

LAG-3-Expressing Tumor-Infiltrating T Cells Are Associated with Reduced Disease-Free Survival in Pancreatic Cancer

T cells are the predominant immune cell population in the pancreatic tumor microenvironment. High CD8<sup>+</sup> and Th1-polarized CD4<sup>+</sup> T cell infiltration is associated with prolonged survival in human pancreatic ductal adenocarcinoma (PDAC). However, the express...

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Bibliographic Details
Main Authors: Lena Seifert, Ioana Plesca, Luise Müller, Ulrich Sommer, Max Heiduk, Janusz von Renesse, David Digomann, Jessica Glück, Anna Klimova, Jürgen Weitz, Marc Schmitz, Adrian M. Seifert
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
pancreatic cancer
tumor microenvironment
tumor-infiltrating T cells
ICOS
LAG-3
PD-1
Online Access:https://www.mdpi.com/2072-6694/13/6/1297

Internet

https://www.mdpi.com/2072-6694/13/6/1297

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