Serglycin activates pro-tumorigenic signaling and controls glioblastoma cell stemness, differentiation and invasive potential

Despite the functional role of serglycin as an intracellular proteoglycan, a variety of malignant cells depends on its expression and constitutive secretion to advance their aggressive behavior. Serglycin arose to be a biomarker for glioblastoma, which is the deadliest and most treatment-resistant f...

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Bibliographic Details
Main Authors: Dimitra Manou, Panagiotis Bouris, Dimitris Kletsas, Martin Götte, Burkhard Greve, Aristidis Moustakas, Nikos K. Karamanos, Achilleas D. Theocharis
Format: Article
Language:English
Published: Elsevier 2020-05-01
Series:Matrix Biology Plus
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2590028520300144