Complex Interaction Between Low-Frequency APD Oscillations and Beat-to-Beat APD Variability in Humans Is Governed by the Sympathetic Nervous System

Complex Interaction Between Low-Frequency APD Oscillations and Beat-to-Beat APD Variability in Humans Is Governed by the Sympathetic Nervous System

BackgroundRecent clinical, experimental and modeling studies link oscillations of ventricular repolarization in the low frequency (LF) (approx. 0.1 Hz) to arrhythmogenesis. Sympathetic provocation has been shown to enhance both LF oscillations of action potential duration (APD) and beat-to-beat vari...

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Bibliographic Details
Main Authors: Stefan Van Duijvenboden, Bradley Porter, Esther Pueyo, David Adolfo Sampedro-Puente, Jesus Fernandez-Bes, Baldeep Sidhu, Justin Gould, Michele Orini, Martin J. Bishop, Ben Hanson, Pier Lambiase, Reza Razavi, Christopher A. Rinaldi, Jaswinder S. Gill, Peter Taggart
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-01-01
Series:Frontiers in Physiology
Subjects:
action potential duration
beat-to-beat variability
oscillations
human heart
sympathetic
beta-adrenergic blockade
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.01582/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.01582/full

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