Convenient Synthesis and Biological Evaluation of Modafinil Derivatives: Benzhydrylsulfanyl and Benzhydrylsulfinyl [1,2,3]triazol-4-yl-methyl Esters

Convenient Synthesis and Biological Evaluation of Modafinil Derivatives: Benzhydrylsulfanyl and Benzhydrylsulfinyl [1,2,3]triazol-4-yl-methyl Esters

Simple synthesis and biological activities of modafinil derivatives are described. The key reactions include condensation of acid and propargyl alcohol, subsequent 1,3-dipolar cycloaddition reaction of alkynes and (3-azido-propyl)cyclohexane or (4-azido-butyl)benzene in the presence of sodium ascorb...

Full description

Bibliographic Details
Main Authors: Seikwan Oh, Mankil Jung, Eunyoung Lim, Jee-Young Son, Yeonju Lee, Jae-Chul Jung
Format: Article
Language:English
Published: MDPI AG 2011-12-01
Series:Molecules
Subjects:
benzhydrylsulfanyl-[1,2,3]triazol-4-yl-methyl ester
benzhydrylsulfinyl-1,2,3]triazol-4-yl-methyl ester
NO-generation
condensation
1,3-dipolar cycloaddition reaction
Online Access:http://www.mdpi.com/1420-3049/16/12/10409/

Internet

http://www.mdpi.com/1420-3049/16/12/10409/

Similar Items