Saponins enhance exon skipping of 2′-O-methyl phosphorothioate oligonucleotide in vitro and in vivo

Saponins enhance exon skipping of 2′-O-methyl phosphorothioate oligonucleotide in vitro and in vivo

Mingxing Wang, Bo Wu, Sapana N Shah, Peijuan Lu, Qilong Lu McColl-Lockwood Laboratory for Muscular Dystrophy Research, Department of Neurology, Cannon Research Center, Carolinas Medical Center, Charlotte, NC 28203, USA Background: Antisense oligonucleotide (ASO)-mediated exon skipping has been fea...

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Bibliographic Details
Main Authors: Wang M, Wu B, Shah SN, Lu P, Lu Q
Format: Article
Language:English
Published: Dove Medical Press 2018-10-01
Series:Drug Design, Development and Therapy
Subjects:
Antisense delivery
2′-OMePS
Exon-skipping
Saponin
Muscular dystrophy
Online Access:https://www.dovepress.com/saponins-enhance-exon-skipping-of-2prime-o-methyl-phosphorothioate-oli-peer-reviewed-article-DDDT

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https://www.dovepress.com/saponins-enhance-exon-skipping-of-2prime-o-methyl-phosphorothioate-oli-peer-reviewed-article-DDDT

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