Thrombopoiesis is spatially regulated by the bone marrow vasculature

Thrombopoiesis is spatially regulated by the bone marrow vasculature

Megakaryocyte maturation is thought to occur as the cells migrate from a vessel-distant (endosteal) niche to the vessel within the bone. Here, the authors show that megakaryocytes represent largely sessile cells in close contact with the vasculature and homogeneously distributed in the bone marrow.

Bibliographic Details
Main Authors: David Stegner, Judith M. M. vanEeuwijk, Oğuzhan Angay, Maximilian G. Gorelashvili, Daniela Semeniak, Jürgen Pinnecker, Patrick Schmithausen, Imke Meyer, Mike Friedrich, Sebastian Dütting, Christian Brede, Andreas Beilhack, Harald Schulze, Bernhard Nieswandt, Katrin G. Heinze
Format: Article
Language:English
Published: Nature Publishing Group 2017-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00201-7

Internet

https://doi.org/10.1038/s41467-017-00201-7

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