Thrombopoiesis is spatially regulated by the bone marrow vasculature
Megakaryocyte maturation is thought to occur as the cells migrate from a vessel-distant (endosteal) niche to the vessel within the bone. Here, the authors show that megakaryocytes represent largely sessile cells in close contact with the vasculature and homogeneously distributed in the bone marrow.
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Nature Publishing Group
2017-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00201-7 |
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doaj-e135bb3de3894d00826f43b38e69be3f2021-01-31T12:25:41ZengNature Publishing GroupNature Communications2041-17232017-07-018111110.1038/s41467-017-00201-7Thrombopoiesis is spatially regulated by the bone marrow vasculatureDavid Stegner0Judith M. M. vanEeuwijk1Oğuzhan Angay2Maximilian G. Gorelashvili3Daniela Semeniak4Jürgen Pinnecker5Patrick Schmithausen6Imke Meyer7Mike Friedrich8Sebastian Dütting9Christian Brede10Andreas Beilhack11Harald Schulze12Bernhard Nieswandt13Katrin G. Heinze14Institute of Experimental Biomedicine, University Hospital WürzburgInstitute of Experimental Biomedicine, University Hospital WürzburgRudolf Virchow Center for Experimental Biomedicine, University of WürzburgInstitute of Experimental Biomedicine, University Hospital WürzburgInstitute of Experimental Biomedicine, University Hospital WürzburgRudolf Virchow Center for Experimental Biomedicine, University of WürzburgRudolf Virchow Center for Experimental Biomedicine, University of WürzburgLaboratory of Pediatric Molecular Biology, Charité-University Hospital BerlinRudolf Virchow Center for Experimental Biomedicine, University of WürzburgInstitute of Experimental Biomedicine, University Hospital WürzburgDepartment of Medicine II and Interdisciplinary Center for Clinical Research (IZKF), University Hospital WürzburgDepartment of Medicine II and Interdisciplinary Center for Clinical Research (IZKF), University Hospital WürzburgInstitute of Experimental Biomedicine, University Hospital WürzburgInstitute of Experimental Biomedicine, University Hospital WürzburgRudolf Virchow Center for Experimental Biomedicine, University of WürzburgMegakaryocyte maturation is thought to occur as the cells migrate from a vessel-distant (endosteal) niche to the vessel within the bone. Here, the authors show that megakaryocytes represent largely sessile cells in close contact with the vasculature and homogeneously distributed in the bone marrow.https://doi.org/10.1038/s41467-017-00201-7 |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
David Stegner Judith M. M. vanEeuwijk Oğuzhan Angay Maximilian G. Gorelashvili Daniela Semeniak Jürgen Pinnecker Patrick Schmithausen Imke Meyer Mike Friedrich Sebastian Dütting Christian Brede Andreas Beilhack Harald Schulze Bernhard Nieswandt Katrin G. Heinze |
| spellingShingle |
David Stegner Judith M. M. vanEeuwijk Oğuzhan Angay Maximilian G. Gorelashvili Daniela Semeniak Jürgen Pinnecker Patrick Schmithausen Imke Meyer Mike Friedrich Sebastian Dütting Christian Brede Andreas Beilhack Harald Schulze Bernhard Nieswandt Katrin G. Heinze Thrombopoiesis is spatially regulated by the bone marrow vasculature Nature Communications |
| author_facet |
David Stegner Judith M. M. vanEeuwijk Oğuzhan Angay Maximilian G. Gorelashvili Daniela Semeniak Jürgen Pinnecker Patrick Schmithausen Imke Meyer Mike Friedrich Sebastian Dütting Christian Brede Andreas Beilhack Harald Schulze Bernhard Nieswandt Katrin G. Heinze |
| author_sort |
David Stegner |
| title |
Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| title_short |
Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| title_full |
Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| title_fullStr |
Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| title_full_unstemmed |
Thrombopoiesis is spatially regulated by the bone marrow vasculature |
| title_sort |
thrombopoiesis is spatially regulated by the bone marrow vasculature |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2017-07-01 |
| description |
Megakaryocyte maturation is thought to occur as the cells migrate from a vessel-distant (endosteal) niche to the vessel within the bone. Here, the authors show that megakaryocytes represent largely sessile cells in close contact with the vasculature and homogeneously distributed in the bone marrow. |
| url |
https://doi.org/10.1038/s41467-017-00201-7 |
| work_keys_str_mv |
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