Quantitative Proteomic Approach Reveals Altered Metabolic Pathways in Response to the Inhibition of Lysine Deacetylases in A549 Cells under Normoxia and Hypoxia

Quantitative Proteomic Approach Reveals Altered Metabolic Pathways in Response to the Inhibition of Lysine Deacetylases in A549 Cells under Normoxia and Hypoxia

Growing evidence is showing that acetylation plays an essential role in cancer, but studies on the impact of KDAC inhibition (KDACi) on the metabolic profile are still in their infancy. Here, we analyzed, by using an iTRAQ-based quantitative proteomics approach, the changes in the proteome of <i&...

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Bibliographic Details
Main Authors: Alfonso Martín-Bernabé, Josep Tarragó-Celada, Valérie Cunin, Sylvie Michelland, Roldán Cortés, Johann Poignant, Cyril Boyault, Walid Rachidi, Sandrine Bourgoin-Voillard, Marta Cascante, Michel Seve
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:International Journal of Molecular Sciences
Subjects:
cancer metabolism
lysine deacetylase inhibitors
hypoxia
NSCLC
Online Access:https://www.mdpi.com/1422-0067/22/7/3378

Internet

https://www.mdpi.com/1422-0067/22/7/3378

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