α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin

α7 Nicotinic Acetylcholine Receptor Signaling Modulates Ovine Fetal Brain Astrocytes Transcriptome in Response to Endotoxin

Neuroinflammation in utero may result in lifelong neurological disabilities. Astrocytes play a pivotal role in this process, but the mechanisms are poorly understood. No early postnatal treatment strategies exist to enhance neuroprotective potential of astrocytes. We hypothesized that agonism on α7...

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Bibliographic Details
Main Authors: Mingju Cao, James W. MacDonald, Hai L. Liu, Molly Weaver, Marina Cortes, Lucien D. Durosier, Patrick Burns, Gilles Fecteau, André Desrochers, Jay Schulkin, Marta C. Antonelli, Raphael A. Bernier, Michael Dorschner, Theo K. Bammler, Martin G. Frasch
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-05-01
Series:Frontiers in Immunology
Subjects:
neuroinflammation
LPS
CHRNA7
RNAseq
astrocyte
microglia
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01063/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01063/full

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